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Eleonore DUPUIS

Master in biomedical sciences ULB - 2015

Aantal beurzen:
2017-2018 | 2018-2019 | 2019-2020: "Bourse Isabelle de Borchgrave"


Characterization in zebrafish of the molecular networks oh the myotubularin/amphiphysin 2/Dynamin 2 pathway involved in centronuclear myopathies

Project supervisor

Nicolas Deconinck & Sabine Costagliola

Labo of hospitaal waar het project plaatsvindt


Objectives of research

Physiopathology of centronuclear myopathies (CNM) is still incompletely understood. Several genes as myotubularin, amphiphysin 2 and dynamin 2 are known to be involved in this fatal disease. But the link between the mutated genes and the physiopathology of the disease is still poorly understood. We have thus decided to generate mtm1 zebrafish model to study the molecular interactions between the three genes in vivo. We are currently performing mutant characterization to understand the effect of the mutation on the phenotype. Next, as zebrafish are well suited for high-throughput drug screening, our mutant could be an excellent model to test drugs.

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